Sommarutide is a long-acting formulation based on the basic structure of Liraglutide, which is more effective in the treatment of type 2 diabetes. Sommarutide was prepared by solid-liquid synthesis method. ptide Aib8, Arg34GLP-1(7-37) and alitic acylating agent were prepared by solid-se synthesis. Under alkaitions, the synthetic alitic acylating agent was used to modify the ptide Lys26 to obtain sommaruteptide. The biological activity of the self-made samples was determined by time-resolved fluorescence resonance energy transfer immunoassay.
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