Coppertripeptide (GHK-Cu) is a naturally occurring tripeptide first isolated from human plasma but can also be found in saliva and urine. During wound healing, Coppertripeptide can be proteolytically removed from existing extralar proteins and used as a chemoattractant for inflammatory and endothelial . Coppertripeptide increases the production of messenger RNA from collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts. Coppertripeptide is a natural modulator of multiple lar pathways in skin regeneration.