GW501516, GW-501, 516, GW1516, GSK-516

GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in a collaboration between Ligand rmaceuticals and GlaxoSmithKhe 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.In 2007 research was published showing that high doses of GW501516 given to mice dramatically improved their sical performance; the work was widely discussed in popular media, and led to a black market for the drug candidate and to its abuse by athletes as a doping agent. The World Anti-Doping Agency (WADA) developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009; it has issued additional warnings to athletes that GW501516 is not safe.

ProName：

2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)nyl]-1,3-thiazol-5-yl]methylsulfanyl]noxy]acetic acid

Other Names：

2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)nyl)-5-(thiazolyl)methyl)thio)noxy)acetic acid;

Endurobol;

2-(2-BROMONYL)-3'-TRIFLUOROMETHYLACETONONE;

{2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)nyl]-5-thiazolyl}methylthio}noxy}acetic acid;

GSK-516;

GW1516;

2-(4-((2-(4-(Trifluoromethyl)nyl)-5-methylthiazol-4-yl)methylthio)-2-methylnoxy)acetic acid;

UNII-7I2HA1NU22;

CAS：317318-70-0

MF：C21H18F3NO3S2

Formula Weight：453.49800

Exact Mass：453.06800

PSA：112.96000

LogP：6.20140

Appearance：white solid

Density：1.426 g/cm3

Boiling Point：584.543ºC at 760 mmHg

Flashing Point：307.321ºC

Refractive index：1.619

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