500IU Ipsen UK

500IU

contains the substance called botulinum as its active ingredient. Inactive ingredients of include human albumin, lactose and protein from cow’s milk.

was originally developed for the treatment of neurological and ohalmic conditions in the early 1990s in the United Kingdom and has established clinical success. Patients with excessive sweating under the armpits (axillary hyperhidrosis) are also treated with this product.

is manufactured by Ipsen Biorm Ltd., a British company with headquarters in Wrexham, UK. is exclusively distributed by Tercica, Inc., a subsidiary company of Ipsen Group with headquarters at Brisbane, CA and Medicis Aesthetics Inc., a wholly owned subsidiary of Medicis rmaceutical Corporation with headquarters at Scottsdale, AZ.

rmacological Action

contains substance called botulinum that relaxes the muscle. Botulinum ved from Clostridium botulinum bacteria that intercept the discharge of acetylcho the nerve endings that causes the contraction of muscles.

For the improvement of the appearance of glabellar sport temporarily impede the tightening of muscles found between the eyebrows for about 4 months.

For the treatment of abnormal head position and neck pain caused by cervical dystonia (CD), lessens the muscle spasm that causes the CD by softening the muscle for about 12 to 16 weeks. Neck pain and abnormal head position as symptoms to CD is thereby reduced.

works in two functions, which is by inhibiting the release of acetylchoat the same time blocks the neuromuscular activity.

Indication

is indicated for the treatment of the following conditions specifically indicated in the medication guide:

Abnormal head position (spasmodic torticolitis) and neck pain brought about by the condition called cervical dystonia (CD) in adults, Temporary improve the appearance of moderate to severe frown nd between the eyebrows (glabellar patients younger than 65 years old.

500IU? is also prescribed for the medication of the following condition:

Arm spasticity (stiffness in the arm muscles) that occurs following a stroke. Equinus foot deformity (abnormal ankle position and walking gait) caused by cerebral palsy spasticity in children 2 years old or older. Blerospasm (a condition affecting the eyelid). This condition losses the persons’ control on the blinking and closure of his eyelids. Hemifacial spasm (a condition affecting the face muscle). Persons’ affected with this condition losses control on his face muscle, enabling it to contract without control.

Mode of Administration

is administered through intramuscular injection on the affected muscles. It should be performed by a health care provider who is trained and has the skill of identifying the essential attributes of muscles.

For the treatment of cervical Dystonia: is administered with the initial divided dose of 500IU? given through intramuscular injection in affected muscles. Depending upon the result of treatment and patient’s response to medication, may be administered every 12-16 weeks or as prescribed by Doctor with a dosage between 250 to 1000 units.

For the improvement of Glabellar sport is administered intramuscularly in the affected muscles not exceeding the total dose of 50 Units, divided in 10 aliquot units or for 5 equal dosages.

Intervals or frequency for re-treatment must not transpire less than 3 months (12 weeks) following the previous injection or administration.

Contraindications and Cautions

is contraindicated to persons who have an allergic reaction to any ingredients. It is important to inform your Doctor if you have either an infection on the possible site for injection or are allergic to the following substance:

Protein from cow’s milk Botulinum Boc

Persons who have the following symptoms or conditions are advised to tell your Doctor of your concern and the possible effect of on your current condition:

Asthma or Emsema Abnormal sugar level or Diabetes Bleeding problems Irregular heartbeat

and Breastfeeding. It is not known whether passes in to breast milk. It is however important to inform your Doctor if you are breast feeding a baby to avoid harm to the nursing infant.

and Pregnancy. FDA classified under the C category for pregnancy. should be used with caution on pregnant women, as such; benefits should exceed the risk that is involved in the use of this medication.

may cause muscle weakness and must not be taken by persons who are operating machinery or driving a vehicle.

is generally not recommended to patients under 18 years old.

Side Effects

Like any medication, side effects may occur on the use of this medication. The side effect that is associated on the use of varies from moderate to serious classification.

Moderate or less serious side effects: The following side effects will diminish after couple of hours:

Discomfort and pain at the injection site Headache Tired feeling Muscle pain Neck pain Mild allergic reaction such as itching, rash, dizziness and faint Dropping eyelids Blurred vision

Serious side effects: Immediately seek medical intervention if any of the following side effects occurs. Spread of se serious side effects in the area outside the injection site and is usually accompanied by the following symptoms:

Dysnia (change or loss of voice or the occurrence of hoarse voice ) Dysarthria ( trouble speaking a word clearly) Breathing trouble Swallowing problem Severe wheezing and asthma symptoms Loss of bladder control

It is important to inform your doctor right away if you have any discomfort or unnatural occurrence in your present condition.

Drug Interactions

Drug interactions will normally affect the efficacy of the treatment. There is no solid study that is conducted on the possible interaction of to certain medication.

The following treatment that interferes with neuromuscular transmission may affect the efficacy of :

Aminoglycosides (curare-like agents) Antichodrugs Other Botulinum Neuro>It is however important to inform your medical practitioner of any medication you are currently taking for him to have a complete assessment of its possible interaction with .

Interesting facts

is already existing for more than 2 decades and was first to have gained the approval for treatment of neuromuscular conditions in New Zealand.

Currently, it has received the approval for the treatment of frown excessive sweating under the armpits. Such fact is registered under the New Zealand Medicines Act.

Review:

“I tried after my friend recommends the product to me. I basically use Boy and was able to compare the effects between the two products.

BoI felt it effects 3 days after the injection. After using , I am amazed of the result; I already felt it one day after. It definitely works better than Boffect last longer. is simply amazing.”

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