Description:
Levetiracetam is a white crystaler chemical. The chemical name is (S)-α-ethyl-2-oxo-1-pyrrolidineacetamide, the molecular formula is C8H14N2O2, and the molecular weight is 170.20900. Levetiracetam is an antiepileptic drug, which is mainly used clinically for the additional treatment of partial seizures in adults and children over 4 years old with epilepsy.,
Levetiracetam is a pyrrolidone derivative whose chemical structure is not related to existing antiepileptic drugs. The exact mechanism of levetiracetam's antiepileptic effect is unknown. Protective effects observed with levetiracetam against generalized seizures secondary to focal seizures induced by pilocarpine and kainic acid, two chemical convulsants that mimic the complex parts associated with secondary generalized seizures in some individuals Characteristics of sex seizures. Levetiracetam has inhibitory effects on both the ignition process and the ignition state in the rat model of complex partial seizures. In vitro and in vivo experiments showed that levetiracetam inhibited hippocampal epileptiform burst discharges, suggesting that levetiracetam may selectively inhibit the supersynchrony of epileptiform burst discharges and the spread of seizures. At concentrations as high as 10 uM, levetiracetam has no affinity for several known receptors, such as benzodiazepines, GABA, glycine, NMDA, reuptake sites, and second messenger systems. In vitro studies have shown that levetiracetam has no effect on neuronal voltage-gated sodium channels or T-type calcium currents. Studies have shown that levetiracetam antagonizes the activity of negative regulators of GABA and glycine-gated currents in cultured neurons. A saturable and stereoselective neuronal binding site for levetiracetam was found in rat brain tissue.
Application:
(1) The (S)-enantiomer of the ethyl analogue of levetiracetam. used as an anticonvulsant
(2) The (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of levetiracetam (P500800). used as an anticonvulsant
(3) A compound that inhibits pulse discharge without affecting the excitability of normal neurons
(4) For the adjuvant treatment of partial seizures in adults and children aged 4 and above.
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