| Purity | 99%min |
| Melting point | 1800°C |
| MW | 458.93 |
| Storage temp. | Desiccate at RT |
| Solubility | DMSO: ≥20mg/mL |
| Color | White to tan |
| Form | Solid |
| Merck | 14,9420 |
Product Name: | Tianeptine sodium |
Synonyms: | TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide |
CAS: | 30123-17-2 |
MF: | C21H24ClN2NaO4S |
MW: | 458.93 |
EINECS: | 250-059-3 |
Mol File: |
Item | Specifications | Results |
Description
| White to yellowish powder,very hygroscopic. | Off-white powder,very hygroscopic. |
Solubility
| Freetly soluble In water and methanol and dichloromethane | Complies
|
Identification
| (1)By IR, To match with working standard | Complies |
| (2)It gives reaction of sodium | Complies |
Impurities A | ≤0.1% | Not detected |
Related compounds | Any impurity ≤0.1% | <0.1% |
| Total impurities ≤0.4% | 0.03% |
Residual Solvents | Acetidin≤ 0.5% | Not detected |
| Dichloromethane≤ 0.06% | Not detected |
| Methanol≤ 0.3% | Not detected |
| Acetone≤ 0.5% | Not detected |
| Acetonitrile≤0.041% | Not detected |
| Ethanol≤0.5% | Not detected |
| N, N-dimethylformamide | Not detected |
Water | ≤ 5.0% | 2.575% |
Assay | 99.0%-101.0% | 99.97% |
Conclusion | The results conforms with EP8.0 standards | |
Tianeptine sodium 30123-17-2
Tianeptine is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different rmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
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