| Product name | J147 |
| CAS | 1146963-51-0 |
| MF | C18H17F3N2O2 |
| Molecular Weight | 350.33 |
J147 was discovered based upon efficacy in multiple culture models of age-associated pathologies rather than exclusively amyloid metabolism. It is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. The neurotroc and memory-enhancing activities of J147 are associated with an increase in brain derived neurotroc factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques, etc. These pleiotroc effects of a single molecule suggest that J147 has potential for the treatment of AD.
Product name | J147 |
CAS NO. | 1146963-51-0 |
Category | rmaceutical Raw Materials,Active rmaceutical Ingredients,Bulk Drugs,Fine Chemicals. |
Purity | 99% |
Appearance | White powder |
Shelf life | 2 years |
Usage | J147 is an Neurotroc compound. |
Storage | J147 should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. |
Product Name | j147 | Other Name | J-147 Powder | |
Purity | 99%min | CAS No. | 1146963-51-0 | |
Appearance | White crystaler | M.W. | 350.33 | |
MOQ | 1g | M.F. | C18H17F3N2O2 | |
Loss on drying | <3.0% | Test Methord | HPLC | |
Item | Specification | Result | ||
Appearance | White crystaler | Complies | ||
Related substance (HPLC) | Total impurity ≤0.5% Max single impurity ≤0.1% | 0.2% 0.06% | ||
Odor | Characteristic | Complies | ||
Assay | 99% | 99.14% | ||
Heavy Metal | <10ppm | Complies | ||
As | <0.1ppm | 0.05ppm | ||
Pb | <0.1ppm | 0.05ppm | ||
Cd | <0.1ppm | 0.05ppm | ||
Residual Solvents | <100ppm | Complies | ||
Residual Pesticide | Negative | Complies | ||
Total Plate Count | <1000cfu/g | Complies | ||
Yeast & Mold | <100cfu/g | Complies | ||
E.Coli | Negative | Complies | ||
Salmonella | Negative | Complies | ||
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