Product information | |
A DNA sequence encoding the extralar domain of human IL-15 (NP_000576.1) was expressed with the C-terminal fused Fc region of human IgG1. | Â |
Human | Â |
CHO | Â |
> 95 % as determined by SDS-PAGE | Â |
The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2×106 units/mg. |  |
< 0.01EU per μg of the protein as determined by the LAL method |  |
The recombinant human IL-15 consists of 362 amino acids and predicts a molecular mass of 45 kDa. | Â |
Lyolized from sterile PBS, 7.4. Normally 6 % - 8 % trehalose, mannitol are added as protectants before lyolization. | Â |
Samples are stable for up to 24 months from date of receipt at 4 ℃ . Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |  |
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Background | |
The protein encoded by IL-15 gene is a cytokine that regulates T and natural killer activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The of CD8+ memory is shown to be controlled by a balance between IL-15 and IL2. IL-15 induces the activation of JAK kinases, as well as the srylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that IL-15 may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. | |
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