Product information | |
A DNA sequence encoding the extralar domain of human IL-7 (NP_000871.1) was expressed with the C-terminal fused Fc region of human IgG1. | Â |
Human | Â |
CHO | Â |
> 95 % as determined by SDS-PAGE | Â |
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2×106 units/mg. |  |
< 0.01EU per μg of the protein as determined by the LAL method |  |
The recombinant human IL-7 consists of 395 amino acids and predicts a molecular mass of 42.5 KDa. | Â |
Lyolized from sterile PBS, 7.4. Normally 6 % - 8 % trehalose, mannitol are added as protectants before lyolization. | Â |
Samples are stable for up to 24 months from date of receipt at 4 ℃ . Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |  |
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Background | |
IL-7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal in the bone marrow and thymus. IL-7 stimulates the proliferation of lymid progenitors. Produced by thymic stromal , spleen and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T in combination with other factors, such as ConA and IL-2. It is important for proliferation during certain stages of B-maturation. IL-7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T receptor beta (TCRß) during early T development. IL7 can be produced locally by intestinal epithelial and epithelial goblet , and may serve as a regulatory factor for intestinal mucosal lymcytes. IL-7 is a hematopoietic growth factor that primarily affects early B and T . | |
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