Sodium Sulfate

Anhydrous Sodium Sulte BP ( Sodium Sulfate )

Anhydrous Sodium Sulte BP Eur Grade Specifications

Na2SO4Action and use: Laxative.

DEFINITIONContent98.5 per cent to 101.0 per cent (dried substance).

CHARACTERSAppearance: White or almost white powder, hygroscopic.Solubility: Freely soluble in water.

IDENTIFICATIONA. It gives the reactions of sultes.B. It gives the reactions of sodium.C. It complies with the test for loss on drying (see Tests).

TESTSSolution S: Dissolve 2.2 g Sodium Sulfate in carbon dioxide-free water R prepared from distilled water and dilute to 100 ml with the same solvent.Appearance of solution: Solution S is clear and colourless.Acidity or alkalinity: To 10 ml of solution S add 0.1 ml of bromothymol blue solution R1. Not more than 0.5 ml of 0.01 M hydrochloric acid or 0.01 M sodium hydroxide is required to change the colour of the indicator.Chlorides: Maximum 450 ppm.Calcium: Maximum 450 ppm, if intended for use in the manufacture of parenteral dosage forms.Iron: Maximum 90 ppm, if intended for use in the manufacture of parenteral dosage forms.Magnesium: Maximum 200 ppm, if intended for use in the manufacture of parenteral dosage forms. To 10 ml of solution S add 1 ml of glycerol (85 per cent), 0.15 ml of titan yellow solution, 0.25 ml of ammonium oxalate solution and 5 ml of dilute sodium hydroxide solution and shake. Any pink colour in the test solution is not more intense than that in a standard prepared at the same time in the same manner using a mixture of 5 ml of magnesium standard solution (10 ppm Mg) and 5 ml of water.Heavy metals: Maximum 45 ppm.Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 130C.

Sodium Sulfate USP Grade Specifications

Sodium SulfateNa2SO4-10H2O -- 322.20Sulfuric acid disodium salt, decahydrate.Disodium sulfate decahydrate CAS 7727-73-3Anhydrous 142.04 CAS 7757-82-6

Sodium Sulfate contains ten molecules of water of hydration, or is anhydrous. It contains not less than 99.0 percent of Na2SO4, calculated on the dried basis.

Identification: A solution (1 in 20) responds to the tests for Sodium 191 and for Sulfate.Acidity or alkalinity: To 10 mL of a solution, containing the equivalent of 1.0 g of Na2SO4·10H2O in 20 mL of water, add 1 drop of bromothymol blue TS: not more than 0.50 mL of either 0.010 N hydrochloric acid or 0.010 N sodium hydroxide is required to change the color of the solution.Loss on drying: Dry at 105 for 4 hours: the decahydrate loses between 51.0% and 57.0% of its weight, and the anhydrous form loses not more than 0.5% of its weight.Chloride: A portion equivalent to 1.0 g of Na2SO4·10H2O ( Sodium Sulfate Decahydrate )shows no more chloride than corresponds to 0.30 mL of 0.020 N hydrochloric acid (0.02%).