Potassium Chloride

Potassium Chloride USP Grade Specifications

Potassium Chloride USPKCl 74.55

Assay— Potassium Chloride contains not less than 99.0 percent and not more than 100.5 percent of KCl, calculated on the dried basis.Packaging and storage— Preserve in well-closed containers.Labeling— Where intended for use in hem dialysis, it is so labeled.Identification— A solution (1 in 20) responds to the tests for Potassium and for Chloride.Acidity or alkalinity— To a solution of 5.0 g in 50 mL of carbon dioxide–free water add 3 drops of nolhalein TS: no pink color is produced. Then add 0.30 mL of 0.020 N sodium hydroxide: a pink color is produced.Loss on drying — Dry it at 105 for 2 hours: it loses not more than 1.0% of its weight.Iodide or bromide—IODIDE—Standard stock solution— Transfer an accurately weighed quantity, about 41 mg, of potassium iodide to a 25-mL volumetric flask. Dissolve in and dilute with water to volume, and mix.Standard solution— Dilute 1.0 mL of Standard stock solution with water to 25 mL, and mix. Dilute 2.0 mL of this solution with water to 8 mL, and proceed as directed for Test solution beginning with “Add 1 mL each of chloroform”.Test solution— Dissolve 2 g in 8 mL of water. Add 1 mL each of chloroform and diluted hydrochloric acid, then add 2 drops of a chloramine T solution (0.1 in 100), and shake gently. The violet color of the chloroform layer is not darker than that of a concomitantly prepared Standard solution: the limit is 0.005%.BROMIDE—Standard solution— Transfer an accurately weighed quantity, about 32 mg, of sodium bromide to a 25-mL volumetric flask. Dissolve in and dilute with water to volume, and mix. Dilute 2.0 mL of this solution with water to 8 mL, and proceed as directed for Test solution beginning with “Add 1 mL each of chloroform”.Test solution— Dissolve 2 g in 8 mL of water. Add 1 mL each of chloroform and diluted hydrochloric acid, then add 5 drops of a chloramine T solution (1 in 100), and shake gently. The brown color of the chloroform layer is not darker than that of a concomitantly prepared Standard solution: the limit is 0.1%.Aluminum— where it is labeled as intended for use in hem dialysis— Proceed as directed using 2.0 g of Potassium Chloride to prepare the Test Preparation: the limit is 1 µg per g.Calcium and magnesium— To 20 mL of a solution (1 in 100) add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and dibasic sodium ste TS: no turbidity is produced within 5 minutes.Sodium— A solution (1 in 20), tested on a platinum impart a pronounced yellow color to a non-luminous flame.Heavy metals— Dissolve 2.0 g in 25 mL of water: the limit is 0.001%.Organic volatile impurities: meets the requirements.