Octyldodecanol

Octyldodecanol BP Eur gradeEurAction and use: Excipient.

DEFINITIONCondensation product of saturated liquid fatty alcohols.Content: Minimum 90 per cent of (2RS)-2-octyldodecan-1-ol (C20H42O; Mr 298.6), the remainder consisting mainly of related alcohols.

CHARACTERSAppearance: Clear, colourless or yellowish, oily liquid.Solubility: Practically insoluble in water, miscible with ethanol (96 per cent).Relative density: About 0.840.Refractive index: About 1.455.

IDENTIFICATIONA. Hydroxyl value (see Tests).B. Thin-layer chromatogra.

TESTSAcidity or alkalinity: Mix 5.0 g thoroughly for 1 min with a mixture of 0.1 ml of bromothymol blue solution, 2 ml of heptane and 10 ml of water. If the aqueous layer is blue, not more than 0.15 ml of 0.01 M hydrochloric acid is required to change the colour of the indicator to yellow. If the aqueous layer is yellow, add 0.45 ml of 0.01 M sodium hydroxide and shake vigorously. After standing to ensure complete separation, the aqueous layer is blue.Optical rotation: - 0.10° to + 0.10°.Hydroxyl value: 175 to 190.Iodine value: Maximum 8.0.Peroxide value: Maximum 5.0.Saponification value: Maximum 5.0.Heavy metals: Maximum 10 ppm.Water: Maximum 0.5 per cent, determined on 2.00 g.Sulted ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY: By Gas chromatogra