PT 141 Validamine CAS:32780-32-8

Peptide PT-141 10mg/vial Bremelanotide

Specifications

Muscle Growth Peptide 32780-32-8 PT-141

Basic Info:

Names: PT-141

Purity: >98%

Appearance: White Powder

Type: rmaceutical Intermediates

CAS No: 32780-32-8

Specification: 10mg/vial

Muscle Growth Peptide 32780-32-8 PT-141 With Safe Delivery

Description

PT-141 (Bremelanotide) is a highly potent synthetic peptide analogue of α-MSH that may elicit aodisiac effects through stimulation of melanocortin receptors. PT-141 (Bremelanotide) consists of seven amino acids and is a cyclic, shortened lactam variant of al-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of siological functions. In studies, bremelanotide was shown to induce lordosis in an animal model and was also effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).

Specification

Name: PT-141

Synonyms: Bremelanotide, PT-141 Acetate

CAS : 189691-06-3

Molecular Formula: C50H68N14O10

Molecular Mass: 1025.2 Da (g/mol)

Amino Acid Sequence: Ac-Nle-cyclo[Asp-His-D--Arg-Trp-Lys]-OH

Purity

PT-141 has a peptide purity level that exceeds 99.0% as determined by HPLC and MS. This peptide was synthesized with no additives and is supplied as a white lyolized (freeze-dried) powder.

Usage

Bremelanotide, similarly to its analogues α-MSH and melanotan II, acts as a non-selective agonist of all of the melanocortin receptors except MC2, where it lacks significant affinity. Reported activity of the drug is as follows:

MC1 (Ki = 0.68 nM)

MC2 (Ki > 1000 nM)

MC3 (Ki = 72.07 nM)

MC4 (Ki = 19.25 nM)

MC5 (Ki = 166.8 nM)

Bremelanotide appears to stimulate sexual desire and arousal completely or mostly via activation of the MC4 receptor (the MC3 receptor may also be involved). It modulates inflammation and limits ischemia via activation of the MC1 and MC4 receptors.

According to Palatin Technologies’ original 2003 patent for bremelanotide, it possesses approximately 50 times the potency of melanotan II as an inducer of erection in male rats. In addition, it was stated in the patent that the therapeutic window of bremelanotide in animals (specifically, the range of induction of the desired sexual arousal relative to the induction of side effects including nausea, yawning, stretching, and decreased appetite) was >1,000-fold, whereas that of melanotan II was only 3- to 4-fold. They concluded that bremelanotide would be more tolerable than melanotan II.

PT-141 and Sexual Dysfunction

PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.

How to use peptide ?

1.) Take an alcohol swab to the stopper of both your peptide vial and the vial of the dilutent.

With a 1cc syringe and draw your preferred dilutent. Choose an amount that will make measuring the final product simple.

1ml(cc) per 10mg vial of Melanotan would mean each 10 mark on a U100 slin syringe would equal 1mg of Melanotan

1ml(cc) per 10 IU vial would mean each 10 mark on a U100 slin syringe would equal 1 IU

2ml(cc) per 10mg vial of Melanotan would mean each 10 mark on a U100 slin syringe would equal 1mg of Melanotan

2ml(cc) added to a 10 IU vial would mean that the 20 mark on a U100 syringe would equal 1 IU

2.) Take the syringe with the dilutent and push it into the vial of lyolized powder letting the dilutent dissolve the peptide.

3.) After all of the dilutent has been added to the vial, gentling swirl (do NOT agitate or violently shake the vial) until the lyolized powder has dissolved and you are left with a clear liquid. The peptide is now ready for use. Store your now reconstituted peptide in the refrigerator.

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