FST Healthy Peptide Follistatin 344 1mg Polypeptide Hormone Follistatin

Name: Follistatin 344Synonyms: FST, FS, Activin-binding proteinAppearance: Sterile Filtered White Lyolized (Freeze-Dried)Purity(by HPLC): >99.00%~99.90%Total Impurities(by HPLC): 1.00%~0.05%Single Impurity(by HPLC): <0.50%~0.08%

Source:Escherichia Coli.sical Appearance: Sterile Filtered White lyolized (freeze-dried) powder

Formulation:Lyolized from a concentrated (1mg/ml) solution containing no additives.

Solubility: It is recommended to reconstitute the lyolized Follistatin in sterile 18MΩ-cm H2O not less

than 100µg/ml, which can then be further diluted to other aqueous solutions.

Purity: Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.Storage Conditions:Aviod Shunshine and Keeping Stoppered

Follistatin 344 Stability: Lyolized Follistatin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.Packing: 1mg/vial,2mg/vial

Follistatin (FS) was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FS is a high-affinity activin-binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid (aa) residues (FS-288) and 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).