Pharmaceutical Grade Local Anesthetic Powder CAS 136-47-0 Tetracaine HCl Powder

rmaceutical Raw Material Tetracaine HCl​​​​​​​

Description

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ohalmology and as an antipruritic, and it has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intralar stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

ApplicationTetracaine hcl is indicated for the production of spinal anesthesia for procedures requiring two to three hours. Parenteral administration of Tetracaine hcl stabilizes the neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia.The onset of action is rapid, and the duration is prolonged (up to two or three hours or longer of surgical anesthesia).Tetracaine hcl is delasma esterases to aminobenzoic acid and diethylaminoethanol.Usage and DosageDo not touch, wipe or rub your eyes after application of this medicine; you could hurt the eye without feeling it. Do not try and put lenses in your eyes until the effect of this medicine has worn off. Follow your doctor's directions.You should not use this medicine yourself except under the direct supervision of your doctor. This medicine should not be used for prolonged periods of time. If your condition does not improve, call your health care professional.