Product Name | Bivalirudin Acetate |
Cas No. | 128270-60-0 |
Molecular Formula | C98H138N24O33 |
Molecular Weight | 2180.33 |
Purity (HPLC) | 99.0%min. |
Appearance | White powder |
Single Impurity (HPLC) | 0.5%max |
Amino Acid Composition | ±10% of theoretical |
Peptide Content (N%) | ≥80.0% |
Water Content (Karl Fischer) | ≤8.0% |
Acetate Content (HPIC) | ≤12.0% |
MS (ESI) | Consistent |
Mass Balance | 95.0~105.0% |
Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
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