Human IL-29(Interleukin 29) ELISA Kit

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Synonyms: IL-29; Interleukin-29; IFNL1; IFN-λ1; Interferon Lambda 1; Cytokine Zcyto21

IL-29(Interleukin 29) Basic information

Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important role in the immune response against pathogenes and especially against viruses by mechanisms similar to type I interferons, but targeting primarily of epithelial origin and hepatocytes. IL-29 is encoded by the IFNL1 gene located on chromosome 19 in humans.[3][5] It is a pseudogene in mice meaning the IL-29 protein is not produced in them. IL-29 exhibits antiviral effects by inducing similar ys as type I interferons. IL-29 receptor JAK-STAT pathways leading to activated expression of interferon-stimulated genes and production of antiviral proteins.[6] Further consequences of IL-29 mprise the upregulated expression of MHC class I molecules,[3] or enhanced expression of the costimulatory molecules and chemokine receptors on pDC, which are the main producers of IFN-α.[

Human IL-29(Interleukin 29) ELISA Kit test method

Feiyue’s Human IL-29(Interleukin 29) Elisa kit is an ELISA reagent for detection of IL-29(Interleukin 29) in Serum, plasma, tissue homogenates, lysates, culture supernates and other biological fluids.

This kit uses sandwich ELISA to detect the concentRation of Human IL-29(Interleukin 29) -specific monoclonal antibody has been pre-coated in the wells of the supplied microplate. Standards samples and controls are added to interact with the immobilized antibody. A sandwich complex is formed by additional anti-Human IL-29(Interleukin 29）antibody with HRP-Streptavidin. TMB solution is added to react with the sandwich for ming optical by microplate reader. The concentRation of Human IL-29(Interleukin 29）in the sample can be calculated by comparing the absorbance of the sample with the standard curve.

Reference:

1, Li MC, Wang HY, Wang HY, Li T, He SH (April 2006). "Liposome-mediated IL-28 and IL-29 expression in A549 and anti-viral effect of IL-28 and IL-29 on WISH ". Acta rmacologica Sinica. 27 (4): 453–9. doi:10.1111/.00292.x. PMID 16539846.

2, Megjugorac NJ, Gallagher GE, Gallagher G (December 2009). "Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29)". Journal of Leukocyte Biology. 86 (6): 1359–63. doi:10.1189/jlb.0509347. PMID 19759281. S2CID 22453858.

3, Uzé G, Monneron D (2007). "IL-28 and IL-29: newcomers to the interferon family". Biochimie. 89 (6–7): 729–34. doi:10.1016/j.biochi.2007.01.008. PMID 17367910.