Apixaban is an anticoagulant used to prevent venous thromboembolism and atrial fibrillation stroke. It is a direct factor Xa inhibitor. Apixaban can be used for antithrombotic therapy in patients with acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI) of atrial fibrillation. Clinical trials have confirmed the safety and effectiveness of Apixaban in patients with atrial fibrillation at the recommended dose. A new oral anticoagulant including xaban combined with P2Y12 inhibitor is currently recommended by North American guidance for preventing stroke and systemic embolism in patients with ACS or PCI with atrial fibrillation.