Quick Details
- Processing Time:within 15days
- Port:huangpu
- Supply Ability: 20000 Kilograms Per Year
- Brand Name:Yuancao(YC)
About mangiferin
A, Introduction of Mangiferin
Name:Mangiferin CAS:4773-96-0 molecular formula:C19H18O11
Molecular weight:422.34
Melting Point:267 ~ 272 ℃
Water solubility: Slightly soluble in water
Properties:
Slightly soluble in methanol, ethanol, water, Soluble in hot dilute methanol, hot dilute
ethanol, not soluble in non-polar solvent
Appearance: Light yellow fine powder
Testing Method: HPLC≥95%
Storage: This product should be sealed and stored in a dry, cool, well-ventilated place,
free from light
Shelf life: 2 years
Main process: ethanol extraction, extraction, chromatography, chromatography, crystallization
Package: 25 kg / cardboard drum for large cargo, the aluminum foil bag for small
sample, net weight 2.5-3kg, diameter 36-40cm, high 50cm. Barrel packaging can also be replaced to
small package as requested, for facility to use.
MOQ: 1kg, label as requested, or our unified label if no request
Transportation: Express or LCL, domestic express to arrive within three days, LCL within five
days to arrive. Quotations are generally inclusive of domestic transportation costs.
Quality: strict accordance with testing standards.
B, Generalize:
1. Properties: melting point 267 ~ 272 ℃ (decomposition). Optical rotation + 43.3 ° (c = 0.9, pyridine),
32 ° (ethanol). Slightly soluble in methanol, ethanol, water, soluble in hot dilute methanol, hot
dilute ethanol, insoluble in non-polar solvents. A Carbonyl glycosides of tetrahydropyrone, double Phenylketone Flavonoids.
2. Plant Source: available in the fruit, leaves, bark of Lacertaceae plant mango (Mangifera
indica L.), available in Rhizome, aerial part of the Anemarrhena asphodeloides Bge., available in the
flower, leaf of iridaceae plants Shegan [Belamcanda chinensis (L.) DC.].
3. Pharmacological functions: Mangiferin has inhibition of the central nervous system,
anti-inflammatory, antibacterial, anti-HSV-2, gallbladder and immune function, to alleviate HSV-2 virus caused by
sacral nerve root disease: the performance of hip or thigh of pain or paresthesia, urinary
retention, it is also associated with proctitis, urethritis syndrome. HSV-2 women, the risk of cervical
cancer than women in general is 5 to 10 times higher. On the simulated high altitude acute
hypoxic liver injury has a protective effect. The main clinical application includes mango cough, mango
cough capsule, mangiferin tablets, mangiferin drop pills, and these agents are limited to respiratory
diseases. Lacertaceae plant mango, in the "open treasure Materia Medica" recorded it is a
thirst-quenching food, cook leaves and drink the soup could cure thirst; "Compendium of Materia Medica"
records that it is the best fruit; "Compendium of Materia Medica Supplements" record of mango can
benefit stomach gas, Stop vomiting. It has been found that mangiferin, which is found in branches,
leaves and bark of mango, has extensive pharmacological effects such as anti-inflammatory, antipyretic,
analgesic, antibacterial, immune regulation, hypoglycemic and antioxidant.
C,Pharmacological effects
1. Antioxidant effect: Due to the particularity of mangiferin structure, there are many phenolic
hydroxyl groups in the molecule, and phenolic hydroxyl group is the important radicals to scavenge
free radical and active oxygen. The mechanism of action of free radicals can be attributed to
two aspects: one on the role of direct free radical scavenging, on the other hand, act on
iron and copper ions and so on, to reduce its further reaction with free radicals.
2. Anti-tumor effect: The occurrence of leukemia is related to the disorder of cell cycle
regulation, and there is a close relationship between cell cycle regulation and telomerase activity
expression. Therefore, the study of telomerase and cell cycle regulation abnormalities has become a new
direction to explore the occurrence and treatment of leukemia.
3. Neuroprotective effect: The mangiferin with polyphenol structure can protect the neurons by
decreasing the influx of Ca2 + and the degree of oxidative stress, thus reducing the cell
death caused by glutamate in the neurons.
4. Antiviral effects: With the in vitro anti-I-type herpes simplex virus (HSV-I) role, the plaque
reduction rate was 56.8%, and its antiviral activity was attributed to its ability to inhibit
intracellular viral replication.
5. Antipyretic effect: It has a good antipyretic effect on endotoxin-induced febrile experimental animal
model, and has a positive correlation with dose, and has a good protective effect on heat
injury.
6. Analgesic effect: The analgesic effect of acetic acid-induced and hot-plate test-induced pain is
significant. Compared with naloxone hydrochloride, analgesic effect induced by mangiferin was not dependent on
opioid receptors, which had a significant analgesic effect and slight effect on peripheral nerves.
7. Anti-parasitic effects: Mangiferin could inhibit the growth of Cryptosporidium parvum in young rats.
Effect of mangiferin on mice infected with nematode and trichinella spiralis.
8. Anti-diabetic effect: After oral administration of mangiferin and glucoside, the blood glucose level
of normal mice was not changed, but the blood glucose concentration of KK-Ay mice model was
decreased and the serum insulin level was also decreased. The mangiferin and glucoside may show
anti-diabetic activity through insulin sensitization.
9. Liver protection and choleretic effect: The protective effect of the liver, mangiferin has a
stable lysosomal membrane effect, and lysosomal acid phosphatase activity has a direct inhibitory effect.
Mangiferin also has obvious choleretic effect.
10. Effects on the central nervous system: Mangiferin has obvious central nervous system excitatory effect. Mangiferin has the effect of scavenging
peroxidative lipid in brain tissue, reducing the damage of peroxidative lipid to neuron, and protecting the normal
function of neuron.
11. The effect on respiratory system: With adrenal glucocorticoid-like anti-inflammatory effect, can reduce capillary
permeability, the anti-inflammatory response rate of 38%. As the anti-inflammatory effect of mangiferin on
bronchial asthma have a certain role, as follows: ① can significantly longer induce-asthma asthma; ②
to reduce the degree of asthma, the incidence of convulsions was significantly lower than the
asthma group; ③ lung The lung / body weight ratio was significantly lower in asthmatic group
than that in asthmatic group, which was close to dexamethasone group. At the same time, mangiferin
can reduce the serum NO and alveolar lavage fluid endothelin-1 (ET-1) levels, the onset of asthma
play a preventive role. Mangiferin combined with dexamethasone can improve efficacy.
12. Anti-radiation: Mangiferin is a natural antioxidant to scavenge free radicals and is also
a natural radiation protection agent. The four phenolic hydroxyl groups in its molecular structure have
electrophilic capacity and the benzene ring is a good energy trap, Molecules by radiation-induced free
radicals to a certain degree of transfer, thereby protecting biological molecules.
13. Others: Mangiferin has effects onantibacterial; anti-inflammatory; antipyretic and immune regulation and
so on. Mangiferin has a clear pharmacological action and a wide variety of plant sources, and
it is mainly used in respiratory diseases in clinical practice.Although mangiferin has been limited in
its clinical application because of its poor solubility, its anti-cancer, Anti-diabetes and other activities,
has get more and more attention. With the deepening of research, mangiferin will have a good
development prospects.
D, Clinical application
1, for the treatment of upper respiratory tract infection
2,Can produce mango cough agent, has a good antitussive anti-infective effect;
3, Mangiferin with erythromycin can prevent acne
4,Mangiferin synergizes oxaliplatin, can promote cancer cell apoptosis, improve the in vitro
anticancer activity of oxaliplatin
E, Security Information
Dangerous Goods Mark: T+,Xi,Xn
Hazard class code: 28-36/37/38-22
Safety instructions: 22-28-36/37-45-36-26
UN#: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS#: OP1927800