NMN β-Nicotinamide Mononucleotide

Nicotinamide mononucleotide (NMN), a derivative of niacin, is a nucleotide that functions as a precursor to nicotinamide adeninedinucleotide (NAD+)[1]. NAD+ is a molecule that holds a variety of functions within the body, mainly through facilitation of cell-signaling enzymes called sirtuins[2]. These enzymes are crucial for normal functioning, with SIRT1 (there are 7 sirtuins) being particularly unique. Research has shown it to be highly active following caloric restriction, which itself brings multiple benefits, including signs of an extending lifespan[3]. Sure enough, further tests have revealed that elevated levels of SIRT1 can lead to protection from metabolic decline and disease[4]. These sirtuins mainly operate through the mitochondria. They act as “message carriers” of sorts – when cell nuclei send signals to the mitochondria, sirtuins (SIRT1 specifically) help make sure the message gets there[5]. We all know how vital proper mitochondrial function is – they aren’t called the “powerhouse of the cell” for nothing! Because sirtuin activity is directly dependent on NAD+ levels[2], NAD+ becomes incredibly important, too!