Quick Details
- Purity:99%min
- Melting point:118-123 °C
- MW:344.49
- MF:C22H32O3
- EINECS:200-351-1
- color:white
- form:powder
- Shelf life:2 Years
- alpha:D25 +83 to +90° (100 mg in 10 ml dioxane)
- Boiling point:419.57°C (rough estimate)
- Density:1.0906 (rough estimate)
- solubility:ethanol: 10 mg/mL
- refractive index:1.5000 (estimate)
- Water Solubility:<0.1 g/100 mL at 24.5 ºC
- Merck:13,9255
- Processing Time:5-7 days
- Port:Qingdao port
- Supply Ability: 1000 Kilograms Per Week
- Brand Name:Sigma
Testosterone propionate, sold under the brand name Testoviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly
in the treatment of low testosterone levels in men.[3][1][4] It has also been used to treat breast cancer in women.[5] It is given by injection into muscle usually once every two to three days.[4][6][7]
Side effects of testosterone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual
desire.[4] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen
receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[8][4] It has strong androgenic effects and moderate anaboliceffects, which make it useful for
producing masculinization and suitable for androgen replacement therapy.[4] Testosterone propionate is a testosterone
ester and a relatively short-acting prodrug of testosterone in the body.[6][3][1] Because of this, it is considered to be a natural and
bioidentical form of testosterone.[9]
Testosterone propionate was discovered in 1936 and was introduced for medical use in 1937.[10][3] It was the first testosterone ester to be marketed, and was the major form of testosterone used in medicine until about
1960.[3][4] The introduction of longer-acting testosterone
esters like testosterone enanthate, testosterone cypionate, and testosterone undecanoate starting in the 1950s resulted in testosterone propionate mostly being
superseded.[3][4] As such, it is rarely used today.[4][11] In addition to its medical use, testosterone propionate is used
to improve physique and performance.[4] The drug is a controlled substance in many countries and so non-medical
use is generally illicit.[4]
Medical uses[edit]
See also: Androgen replacement therapy § Medical uses, and Anabolic steroid § Medical
Testosterone propionate is used primarily in androgen replacement therapy. It is specifically approved for the treatment of hypogonadism in men, breast cancer, low sexual
desire, delayed puberty in boys, and menopausal symptoms.[12]
Side effects[edit]
See also: Anabolic steroid § Adverse effects, and Androgen replacement therapy § Adverse effects
Side effects of testosterone propionate include virilization among others.[4]
Pharmacology[edit]
Pharmacodynamics[edit]
See also: Testosterone § Mechanism of action, and Anabolic steroid § Pharmacology
Testosterone propionate is a prodrug of testosterone and is an androgen and anabolic–androgenic steroid (AAS). That is, it is an agonist of the androgen
receptor (AR).
Pharmacokinetics[edit]
Testosterone propionate is administered in oil via intramuscular injection.[1][2] It has a relatively short elimination half-life and mean residence time of 0.8 days and 1.5 days, respectively.[1][2] As such, it has a short duration of action and must be
administered two to three times per week.[13]
Chemistry[edit]
See also: Androgen ester and List of androgen esters
Testosterone propionate, or testosterone 17β-propanoate, is a synthetic androstane steroid and a derivative of testosterone.[14][15] It is an androgen ester; specifically, it is the
C17β propionate (propanoate) ester of testosterone.[14][15]
History[edit]
Testosterone esters were synthesized for the first time in 1936, and were found to have greatly improved potency relative to testosterone.[10] Among the esters synthesized, testosterone propionate was the most potent, and for this reason, was selected for further development, subsequently being
marketed.[10] Testosterone propionate was introduced in 1937 by Schering AG in Germany under the brand name
Testoviron.[4] It was the first ester of testosterone to be introduced,[3] and was the major form of testosterone used medically before 1960.[4] In the 1950s, longer-acting
testosterone esters like testosterone enanthate and testosterone cypionate were introduced and superseded testosterone propionate.[3] Although rarely used nowadays due to its short duration,[11] testosterone propionate remains
medically available.[4]
Society and culture[edit]
Generic names[edit]
Testosterone propionate is the generic name of the drug and its USAN and BAN.[14][15][16][17] It has also been referred to as testosterone
propanoate or as propionyltestosterone.[14][15][16][17]
Brand names[edit]
Testosterone propionate is or has been marketed under a variety of brand names including Agrovirin, Andronate, Andrusol-P, Masenate, Neo-Hombreol, Oreton, Perandren, Synandrol, Testoviron, and
numerous others.[14][15][16][17]
Availability[edit]
Testosterone propionate appears to no longer be available in the United States.[18]
Legal status[edit]
Testosterone propionate, along with other AAS, is a schedule III controlled substance in the United States under the Controlled Substances Act and
a schedule IV controlled substance in Canada under the Controlled Drugs and Substances Act.[19][20]