Quick Details
- white:powder
- Processing Time:5days
- Port:shanghai
- Supply Ability: 50000 Kilograms Per Year
- Brand Name:dky
Product name:eplerenone
Synonyms:Elperenone;EplerenoneC24H3006;epoxymexrenone;Inspra;EPLERENONE;EPLERINONE;9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone
Methyl Ester;Epleremone;
CAS :
107724-20-9
Quality :
414.20400
MF :
C24H30O6
logP :
3.12450
MW :
414.49100
PSA :
82.20000
Physical and chemical properties
Appearance and properties
white solid
density
1.31 g/cm3
melting point
241-243 DHS C
boiling point
597.9DHS C at 760 MMHG
flash point
259.5 DHS C
refractive index
1.587
vapor pressure
0 MMHG at 25 ° C
Introduction of compounds
Eplerenone (INN) is a steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic
spironolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, glucocorticoid, or estrogenic effects),
and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. By modifying the alternative drug Spironolactone, the new drug was developed in part to
avoid undesired androgenic side effects in male patients. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.
Eplerenone was developed by Pharmacia Corporation, which was acquired by Pfizer in 2002. It was marketed by Pfizer under the trade name Inspra. The US Food and Drug Administration (FDA) approved
the drug for sale in the United States in 2002. Eplerenone is currently approved for sale in the US, EU, Netherlands and Japan. Relative to dosage, eplerenone costs an estimated $2.93 per day
when treating congestive heart failure and $5.86 per day when treating hypertension.
use
Has for aldosterone receptor selectivity, antihypertensive effect is good, the role of durable and other characteristics, and reversible or reduce aldosterone many adverse effects on
cardiovascular.
