Acrylonitrile (AN) BAY 11-7082 Cas 15942-67-7

BAY 11-7082 is an IκBα srylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced srylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse .

Properties

Density: 1.237g/cm3

Boiling Point: 397.6ºC at 760 mmHg

Flash Point: 194.3ºC

Refractive Index: 1.557

Vapor Pressure: 1.57E-06mmHg at 25°C

Molecular Weight 207.3 g/mol

Molecular Formula C10H9NO2S

Appearance:White powder

Purity >98%

CAS 19542-67-7

Solubility Soluble in DMSO at 25 mg/ml or ethanol at 15 mg/ml.