Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication.[1] It is used along with exercise, diet, and weight loss to decrease elevated lipid (fat) levels.[1] It is also used to decrease the risk of heart problems in those at high risk.It is taken by mouth.
Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels.[1] Common side effects include constipation, headaches, and nausea.[1] A lower dose may be needed in people with kidney problems.There is evidence of harm to unborn babies when taken during pregnancy and it should not be used by those who are breastfeeding. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.
Appearance:
white to off- white crystaler
Molecular Weight:
418.57
Density:
1.11 g/cm3
Boiling Point:
564.9 °C at 760 mmHg
Melting Point:
139 °C
Flash Point:
184.8 °C
Storage Temperature:
0-6°C
Refractive index:
1.53
Solubility:
Soluble in DMSO (>25 mg/mL) and ethanol (>25 mg/mL)
Biological Activity:
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle proliferation and migration, and anticancer and anti-inflammatory activity.
Usage:
A competitive inhibitor of HMG-CoA reductase. A synthetic analog of lovastatin
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